The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

The digestive tract plays a central role in the digestion and absorption of nutrients. Far from
being a passive tube, it provides the first line of defense against pathogens and maintains …

In all metazoans, the intestinal tract is an essential organ to integrate nutritional signaling,
hormonal cues and immunometabolic networks. The dysregulation of intestinal epithelium …

The intestine acts as one of the interfaces between an organism and its external
environment. As the primary digestive organ, it is constantly exposed to a multitude of …

Gut homeostasis is controlled by both immune and developmental mechanisms, and its
disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the …

In adult insects, as in vertebrates, the gut epithelium is a highly regenerative tissue that can
renew itself rapidly in response to changing inputs from nutrition, the gut microbiota …

Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this
model is well suited for the study of intestinal stem cell physiology during aging, stress and …

Adult tissue homeostasis requires a tight balance between the removal of old or damaged
cells and the production of new ones. Such processes are usually driven by dedicated stem …

Studies of the adult Drosophila midgut have led to many insights in our understanding of cell-
type diversity, stem cell regeneration, tissue homeostasis, and cell fate decision. Advances …

There is growing interest in using Drosophila melanogaster to elucidate mechanisms that
underlie the complex relationships between a host and its microbiota. In addition to the …