Synaptic vesicle release regulates pre-myelinating oligodendrocyte-axon interactions in a neuron subtype-specific manner

JR Gronseth, HN Nelson, TL Johnson… - Frontiers in Cellular …, 2024 - frontiersin.org
Oligodendrocyte-lineage cells are central nervous system (CNS) glia that perform multiple
functions including the selective myelination of some but not all axons. During myelination …

Myelination induces axonal hotspots of synaptic vesicle fusion that promote sheath growth

RG Almeida, JM Williamson, ME Madden, JJ Early… - Current Biology, 2021 - cell.com
Myelination of axons by oligodendrocytes enables fast saltatory conduction.
Oligodendrocytes are responsive to neuronal activity, which has been shown to induce …

Oligodendrocyte Development in the Absence of Their Target Axons In Vivo

R Almeida, D Lyons - PLoS One, 2016 - journals.plos.org
Oligodendrocytes form myelin around axons of the central nervous system, enabling
saltatory conduction. Recent work has established that axons can regulate certain aspects of …

Individual neuronal subtypes control initial myelin sheath growth and stabilization

HN Nelson, AJ Treichel, EN Eggum, MR Martell… - Neural …, 2020 - Springer
Background In the developing central nervous system, pre-myelinating oligodendrocytes
sample candidate nerve axons by extending and retracting process extensions. Some …

Synaptic proteins expressed by oligodendrocytes mediate CNS myelination

AN Hughes, B Appel - bioRxiv, 2018 - biorxiv.org
Oligodendrocytes ensheath neuronal axons with myelin, a proteolipid-rich membrane that
increases conduction velocity and provides trophic support. Our lab and others have …

Individual neuronal subtypes exhibit diversity in CNS myelination mediated by synaptic vesicle release

S Koudelka, MG Voas, RG Almeida, M Baraban… - Current Biology, 2016 - cell.com
Regulation of myelination by oligodendrocytes in the CNS has important consequences for
higher-order nervous system function (eg,[1–4]), and there is growing consensus that …

Can't wait to myelinate

TD Glenn, WS Talbot - Developmental Cell, 2013 - cell.com
Oligodendrocytes myelinate axons in the central nervous system (CNS). In this issue of
Developmental Cell, Czopka et al.(2013) shed light on the temporal control of myelination by …

Synaptic vesicle fusion along axons is driven by myelination and subsequently accelerates sheath growth in an activity-regulated manner

RG Almeida, JM Williamson, ME Madden, JJ Early… - BioRxiv, 2020 - biorxiv.org
To study activity-regulated myelination, we imaged synaptic vesicle fusion along single
axons in living zebrafish, and found, surprisingly, that axonal synaptic vesicle fusion is …

Emerging concepts in oligodendrocyte and myelin formation, inputs from the zebrafish model

M Masson, B Nait‐Oumesmar - Glia, 2023 - Wiley Online Library
Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS), which
are derived from OL precursor cells. Myelin insulates axons allowing the saltatory …

A subset of oligodendrocyte lineage cells interact with the developing dorsal root entry zone during its genesis

LA Green, RM Gallant, JP Brandt, EL Nichols… - Frontiers in Cellular …, 2022 - frontiersin.org
Oligodendrocytes are the myelinating cell of the CNS and are critical for the functionality of
the nervous system. In the packed CNS, we know distinct profiles of oligodendrocytes are …