We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule
niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this …

Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a
chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are …

We seek to further addresss the questions posed by Moseson et al. regarding whether any
residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion …

Many small-molecule active pharmaceutical ingredients (APIs) exhibit low aqueous
solubility and benefit from generation of amorphous dispersions of the API and polymer to …

Glass transition temperature (T g) is important for amorphous compounds because it can
have implications on their physical and chemical stability. With drugs that possess ionizable …

Oral delivery of poorly water-soluble, weakly basic drugs may be problematic based on the
drugs' intrinsic properties. Many drugs in this subset have overcome barriers to delivery …

The use of amorphous solid dispersions is an interesting strategy to increase the
bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack …

Through matrix crystallization, an amorphous solid may transform directly into its more stable
crystalline state, reducing the driving force for dissolution. Herein, the mechanism of matrix …

A method is described for screening compounds that inhibit crystallization in solution to
enable more accurate measurement of amorphous drug solubility. Three polymers …

Solid dispersion is one of the most effective ways to improve the dissolution of insoluble
drugs. When the carrier can highly disperse the drug, it will increase the wettability of the …