Inflamm-aging was recently affiliated with the progression of diabetic complications. Local
cellular senescence together with senescence-associated secretory phenotype (SASP) are …

Abstract Background and Objective Diabetes accelerates inflammaging in various tissue
with an increase in senescent cell burden and senescence‐associated secretory phenotype …

Hyperglycemia induces chronic low-grade inflammation (inflammaging), which is a newly
identified contributor to diabetes-related tissue lesions, including the inflammatory bone loss …

Aim Pyroptosis and inflamm‐aging have been newly identified to be involved in diabetic
periodontitis. This study aimed to elucidate whether macrophage pyroptosis plays a role in …

Background: The NLRP3 inflammasome is essentially a family of intracellular innate
immune sensors that can respond to bacterial challenge and initiate early host immunity …

Abstract Background and Objective Diabetes influences the frequency and development of
periodontitis. Inflammation of human periodontal ligament cells (HPDLC s) participates in …

Intervertebral disc degeneration is widely recognized as a cause of lower back pain,
neurological dysfunction and other musculoskeletal disorders. The major inflammatory …

Macrophage pyroptosis drives the secretion of IL-1β, which has been recently reported to be
a featured salivary biomarker for discriminating periodontitis in the presence of diabetes …

Overproduction of pro-inflammatory cytokines in the aged, which is called inflammaging,
leads to the deterioration of periodontitis. Toll-like receptor 4 (TLR4) plays a role in the …

Advanced glycation end products (AGEs) are adducts formed on proteins by glycation with
reducing sugars, such as glucose, and tend to form and accumulate under hyperglycemic …