The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

The machinery that transcribes protein-coding genes in eukaryotic cells must contend with
repressive chromatin structures in order to find its target DNA sequences. Diverse arrays of …

The enzymatic machinery that carries out RNA synthesis provides the cell with the means to
adjust the patterns of transcription in response to environmental and developmental signals …

Abstract RNA POLYMERASE II requires multiple general transcription factors to initiate site-
specific transcription1–3. These proteins can assemble in an ordered fashion onto promoter …

RNA polymerase (Pol) III transcribes essential non-coding RNAs, including the entire pool of
transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often …

Transcription of ribosomal RNA by RNA polymerase (Pol) I initiates ribosome biogenesis
and regulates eukaryotic cell growth. The crystal structure of Pol I from the yeast …

Abstract THE RNA polymerase II carboxy-terminal domain (CTD) consists of tandem repeats
of the sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser1–3. The CTD may participate in activated …

An RNA polymerase II promoter has been isolated in transcriptionally activated and
repressed states. Topological and nuclease digestion analyses have revealed a dynamic …

The crystal structure of RNA polymerase II in the act of transcription was determined at 3.3 Å
resolution. Duplex DNA is seen entering the main cleft of the enzyme and unwinding before …

RNA polymerase is an allosteric enzyme whose activity and specificity are controlled by
interaction with a nucleotide, tRNA and proteins. In E. coli the availability of these effectors …