Hematopoietic stem cells (HSCs) possess the ability to sustain the continuous production of
all blood cell types throughout an organism's lifespan. While primarily located in the bone …

During gastrulation, the mouse embryo rapidly undergoes a phase of cell diversification
culminating in the formation of all major tissues, including blood. Due to the small cell …

Rare hematopoietic stem cells (HSCs) can self-renew, establish the entire blood system and
represent the basis of regenerative medicine applied to hematological disorders. Clinical …

Hematopoietic stem cells (HSCs) sustain blood production throughout life and are of pivotal
importance in regenerative medicine. Although HSC generation from pluripotent stem cells …

Hematopoietic stem cells (HSCs) develop during embryogenesis in a complex process that
involves multiple anatomical sites. Once HSC precursors have been specified from …

During gastrulation, the mouse embryo rapidly undergoes a phase of cell diversification
culminating in the formation of all major tissues, including blood. Due to the small cell …

Hematopoietic stem cells (HSC) reside in the bone marrow niche and sustain the production
of blood throughout life. The entire pool of these rare and important cells is generated during …

Hematopoietic stem cells (HSCs) have the ability to self-renew and generate all cell types of
the blood lineages throughout the lifetime of an individual. All HSCs emerge during …

Evidence of the diversity and multi-layered organization of the hematopoietic system is
leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all …

Hematopoietic stem cell (HSC) emergence in the human embryo is spatially and temporally
regulated by highly concerted signals received from the microenvironment. Whilst this …