Denervating the human kidney to improve blood pressure control is an old therapeutic
concept first applied on a larger scale by surgeons in the 1920s. With the advent of modern …

Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive
patients demonstrated a significant reduction of ambulatory blood pressure compared with …

Current therapeutic strategies for these conditions are mainly based on lifestyle
interventions and pharmacological approaches, but the rates of control of blood pressure …

Approximately 8–18% of all patients with high blood pressure (BP) are apparently resistant
to drug treatment. 1, 2 In this situation, new strategies to help reduce BP are urgently needed …

Hypertension imposes a major burden of morbidity and mortality and is associated with
sympathetic nervous system overactivity. Renal sympathetic denervation has been shown to …

Essential hypertension remains one of the biggest challenges in medicine with an enormous
impact on both individual and society levels. With the exception of relatively rare …

Translational medicine is concerned with the translation of research discoveries into clinical
applications for the prevention, diagnosis, and treatment of human diseases. Here we briefly …

Systemic hypertension is a major burden to the individual and society. Its association with
major adverse cardiac and cerebral events and favorable effects of antihypertensive therapy …

Renal afferent and efferent sympathetic nerves are involved in the regulation of blood
pressure and have a pathophysiological role in hypertension. Renal sympathetic …

Clinical trials have shown that catheter-based renal denervation (RD), ie interruption of
afferent and efferent sympathetic nerves supplying the kidney, can reduce systolic blood …