[HTML][HTML] iPHoP: An integrated machine learning framework to maximize host prediction for metagenome-derived viruses of archaea and bacteria

S Roux, AP Camargo, FH Coutinho, SM Dabdoub… - PLoS …, 2023 - journals.plos.org
The extraordinary diversity of viruses infecting bacteria and archaea is now primarily studied
through metagenomics. While metagenomes enable high-throughput exploration of the viral …

[PDF][PDF] RaFAH: Host prediction for viruses of Bacteria and Archaea based on protein content

FH Coutinho, A Zaragoza-Solas, M López-Pérez… - Patterns, 2021 - cell.com
Culture-independent approaches have recently shed light on the genomic diversity of
viruses of prokaryotes. One fundamental question when trying to understand their ecological …

[HTML][HTML] Prokaryotic virus host predictor: a Gaussian model for host prediction of prokaryotic viruses in metagenomics

C Lu, Z Zhang, Z Cai, Z Zhu, Y Qiu, A Wu, T Jiang… - BMC biology, 2021 - Springer
Background Viruses are ubiquitous biological entities, estimated to be the largest reservoirs
of unexplored genetic diversity on Earth. Full functional characterization and annotation of …

Computational approaches to predict bacteriophage–host relationships

RA Edwards, K McNair, K Faust, J Raes… - FEMS microbiology …, 2016 - academic.oup.com
Metagenomics has changed the face of virus discovery by enabling the accurate
identification of viral genome sequences without requiring isolation of the viruses. As a …

Alignment-free oligonucleotide frequency dissimilarity measure improves prediction of hosts from metagenomically-derived viral sequences

NA Ahlgren, J Ren, YY Lu, JA Fuhrman… - Nucleic acids …, 2017 - academic.oup.com
Viruses and their host genomes often share similar oligonucleotide frequency (ONF)
patterns, which can be used to predict the host of a given virus by finding the host with the …

[HTML][HTML] VirFinder: a novel k-mer based tool for identifying viral sequences from assembled metagenomic data

J Ren, NA Ahlgren, YY Lu, JA Fuhrman, F Sun - Microbiome, 2017 - Springer
Background Identifying viral sequences in mixed metagenomes containing both viral and
host contigs is a critical first step in analyzing the viral component of samples. Current tools …

Virtifier: a deep learning-based identifier for viral sequences from metagenomes

Y Miao, F Liu, T Hou, Y Liu - Bioinformatics, 2022 - academic.oup.com
Motivation Viruses, the most abundant biological entities on earth, are important
components of microbial communities, and as major human pathogens, they are …

IMG/VR v. 2.0: an integrated data management and analysis system for cultivated and environmental viral genomes

D Paez-Espino, S Roux, IMA Chen… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Integrated Microbial Genome/Virus (IMG/VR) system v. 2.0 (https://img. jgi. doe.
gov/vr/) is the largest publicly available data management and analysis platform dedicated …

A network-based integrated framework for predicting virus–prokaryote interactions

W Wang, J Ren, K Tang, E Dart… - NAR genomics and …, 2020 - academic.oup.com
Metagenomic sequencing has greatly enhanced the discovery of viral genomic sequences;
however, it remains challenging to identify the host (s) of these new viruses. We developed …

VIDHOP, viral host prediction with deep learning

F Mock, A Viehweger, E Barth, M Marz - Bioinformatics, 2021 - academic.oup.com
Motivation Zoonosis, the natural transmission of infections from animals to humans, is a far-
reaching global problem. The recent outbreaks of Zikavirus, Ebolavirus and Coronavirus are …