Harmonizing the neurobiology and treatment of obsessive-compulsive disorder

WK Goodman, EA Storch… - American Journal of …, 2021 - Am Psychiatric Assoc
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …

Neuroscientifically informed formulation and treatment planning for patients with obsessive-compulsive disorder: a review

DD Dougherty, BP Brennan, SE Stewart… - Jama …, 2018 - jamanetwork.com
Importance Obsessive-compulsive disorder (OCD) is a common and often debilitating
psychiatric illness. Recent advances in the understanding of the neuroscience of OCD have …

Obsessive compulsive disorder and the glutamatergic system

C Kariuki-Nyuthe, B Gomez-Mancilla… - Current opinion in …, 2014 - journals.lww.com
Given the need for more efficacious treatments in OCD, and given emergent findings on the
role of the glutamatergic system in this disorder, there is a need for additional …

Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment

C Pittenger, MH Bloch, K Williams - Pharmacology & therapeutics, 2011 - Elsevier
Obsessive compulsive disorder is prevalent, disabling, incompletely understood, and often
resistant to current therapies. Established treatments consist of specialized cognitive …

Neurobiology of obsessive-compulsive disorder: serotonin and beyond

HGM Westenberg, NA Fineberg, D Denys - CNS spectrums, 2007 - cambridge.org
The evidence for the involvement of the serotonergic system in the pathogenesis of
obsessive-compulsive disorder (OCD) is circumstantial at best, despite being the focus for …

Obsessive–compulsive disorder

DJ Stein, DLC Costa, C Lochner, EC Miguel… - Nature reviews Disease …, 2019 - nature.com
Obsessive–compulsive disorder (OCD) is a highly prevalent and chronic condition that is
associated with substantial global disability. OCD is the key example of the 'obsessive …

Obsessive-compulsive disorder phenotypes: implications for genetic studies

EC Miguel, JF Leckman, S Rauch… - Molecular …, 2005 - nature.com
Obsessive-compulsive disorder (OCD) clinical presentation is remarkably diverse, and can
vary both within and across patients over time. This variability in the phenotypic expression …

Endophenotypes of obsessive–compulsive disorder: rationale, evidence and future potential

SR Chamberlain, L Menzies - Expert review of neurotherapeutics, 2009 - Taylor & Francis
Obsessive–compulsive disorder (OCD) is a heritable and debilitating neuropsychiatric
condition. Attempts to delineate genetic contributions have met with limited success, and …

[HTML][HTML] Treatment-resistant OCD: Pharmacotherapies in adults

PJ Van Roessel, G Grassi, EN Aboujaoude… - Comprehensive …, 2023 - Elsevier
Serotonin reuptake inhibitor (SRI) medications are well established as first-line
pharmacotherapeutic treatment for Obsessive-Compulsive Disorder (OCD). However …

Common and distinct neural correlates of obsessive-compulsive and related disorders

D Mataix-Cols, OA van den Heuvel - Psychiatric Clinics, 2006 - psych.theclinics.com
Neurobiological theories of obsessive-compulsive disorder (OCD) suggest that specific
frontal-subcortical circuits are involved in the symptoms and cognitive deficits associated …