The repair of DNA double-strand breaks (DSBs) occurs via nonhomologous end-joining
(NHEJ) or homologous recombination (HR). These mechanistically distinct pathways are …

Within the nervous system appropriate responses to DNA damage are required to maintain
homeostasis and prevent disease. In this tissue, DNA double-strand breaks (DSBs) initiate a …

Jerold Chun*‡ and David G. Schatz†* Department of Pharmacology Neurosciences
Program Biomedical Sciences Program School of Medicine University of California, San …

We recently demonstrated that human embryonic stem cells (hESCs) utilize homologous
recombination repair (HRR) as primary means of double-strand break (DSB) repair. We now …

Recent progress over the past year has provided new insights into the proteins involved in
nonhomologous end joining. The assembly of Ku and DNA‐dependent protein kinase at …

Repair of DNA double-strand breaks (DSBs) is crucial for maintaining genomic integrity
during the successful development of a fertilized egg into a whole organism. To date, the …

DNA double-strand breaks (DSBs) require a coordinated molecular response to ensure
cellular or organism survival. Many factors required for the DSB response, including those …

DNA double-strand breaks (DSBs) are introduced in cells by ionizing radiation and reactive
oxygen species. In addition, they are commonly generated during V (D) J recombination, an …

Repair of DNA damage by homologous recombination has only recently been established
as an important mechanism in maintaining genetic stability in mammalian cells. The recently …

Repair of DNA double-strand breaks (DSBs) is essential for genomic stability. The most
common DSB repair mechanism in human cells, non-homologous end joining (NHEJ) …