A method for mapping the linear epitopes targeted by the natural antibody response to Zika virus infection using a VLP platform technology
A Fowler, C Ye, EC Clarke, JM Pascale, DS Peabody… - Virology, 2023 - Elsevier
Zika virus (ZIKV), a mosquito-borne pathogen, is associated with neurological complications
in adults and congenital abnormalities in newborns. There are no vaccines or treatments for …
in adults and congenital abnormalities in newborns. There are no vaccines or treatments for …
A novel antigenic site spanning domains I and III of the Zika virus envelope glycoprotein is the target of strongly neutralizing human monoclonal antibodies
SD Graham, HA Tu, BD McElvany, NR Graham… - Journal of …, 2021 - Am Soc Microbiol
Zika virus (ZIKV), a mosquito-transmitted flavivirus, caused a large epidemic in Latin
America between 2015 and 2017. Effective ZIKV vaccines and treatments are urgently …
America between 2015 and 2017. Effective ZIKV vaccines and treatments are urgently …
Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes
RS Sankhala, V Dussupt, G Donofrio, GD Gromowski… - Cell reports, 2023 - cell.com
Zika virus (ZIKV) is an emerging pathogen that causes devastating congenital defects. The
overlapping epidemiology and immunologic cross-reactivity between ZIKV and dengue virus …
overlapping epidemiology and immunologic cross-reactivity between ZIKV and dengue virus …
Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III
Y Wu, S Li, L Du, C Wang, P Zou, B Hong… - Emerging microbes & …, 2017 - Taylor & Francis
The Zika virus (ZIKV), a flavivirus transmitted by Aedes mosquitoes, has emerged as a
global public health concern. Pre-existing cross-reactive antibodies against other …
global public health concern. Pre-existing cross-reactive antibodies against other …
[HTML][HTML] Large-scale analysis of B-cell epitopes of envelope: Implications for Zika vaccine and immunotherapeutic development
I Almansour, R Alfares, H Aljofi - F1000Research, 2018 - ncbi.nlm.nih.gov
Background: Cases of the re-emergence of Zika virus in 2015 were associated with severe
neurologic complications, including Gillien-Barre syndrome in adults and congenital Zika …
neurologic complications, including Gillien-Barre syndrome in adults and congenital Zika …
Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality
S Maciejewski, TJ Ruckwardt, KM Morabito… - Science translational …, 2020 - science.org
The emergence of Zika virus (ZIKV) in the Americas stimulated the development of multiple
ZIKV vaccine candidates. We previously developed two related DNA vaccine candidates …
ZIKV vaccine candidates. We previously developed two related DNA vaccine candidates …
[HTML][HTML] Human antibody response to Zika targets type-specific quaternary structure epitopes
MH Collins, HA Tu, C Gimblet-Ochieng, GJA Liou… - JCI insight, 2019 - ncbi.nlm.nih.gov
The recent Zika virus (ZIKV) epidemic in the Americas has revealed rare but serious
manifestations of infection. ZIKV has emerged in regions endemic for dengue virus (DENV) …
manifestations of infection. ZIKV has emerged in regions endemic for dengue virus (DENV) …
Development of virus-like-particle vaccine and reporter assay for Zika virus
H Garg, M Sedano, G Plata, EB Punke… - Journal of virology, 2017 - Am Soc Microbiol
Recent worldwide outbreaks of Zika virus (ZIKV) infection and the lack of an approved
vaccine raise serious concerns regarding preparedness to combat this emerging virus. We …
vaccine raise serious concerns regarding preparedness to combat this emerging virus. We …
Development of a novel ZIKV vaccine comprised of immunodominant CD4+ and CD8+ T cell epitopes identified through comprehensive epitope mapping in Zika virus …
J Sun, Z Zheng, M Li, Z Liu, X Su, X Jin - Vaccine, 2021 - Elsevier
Zika virus (ZIKV) caused over two million human infections in more than 80 countries around
2015–2016. Current vaccines under development are mostly focused on inducing …
2015–2016. Current vaccines under development are mostly focused on inducing …
Probing Zika virus neutralization determinants with glycoprotein mutants bearing linear epitope insertions
MT Chambers, MC Schwarz, M Sourisseau… - Journal of …, 2018 - Am Soc Microbiol
Zika virus (ZIKV) glycoproteins are the primary target of the humoral immune response. In
this study, we explored the capacity of these glycoproteins to tolerate insertion of linear …
this study, we explored the capacity of these glycoproteins to tolerate insertion of linear …