During ongoing presynaptic action potential (AP) firing, transmitter release is limited by the
availability of release-ready synaptic vesicles (SVs). The rate of SV recruitment (SVR) to …

Presynaptic calcium channel function is critical for converting electrical information into
chemical communication but the molecules in the active zone that sculpt this function are …

Munc13s are presynaptic proteins that mediate synaptic vesicle priming and thereby control
the size of the readily releasable pool of vesicles. During high synaptic activity, Munc13-1 …

The presynaptic active zone protein Munc13 is essential for neurotransmitter release,
playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C2A …

Almost all known forms of fast chemical synaptic transmission require the synaptic hub
protein Munc13. This essential protein has also been implicated in mediating several forms …

Munc13 is a multidomain protein present in presynaptic active zones that mediates the
priming and plasticity of synaptic vesicle exocytosis, but the mechanisms involved remain …

Sensing of and response to transient increases in the residual presynaptic Ca2+ levels are
important adaptive mechanisms that define the short-term plasticity characteristics of …

Munc13-1 plays a crucial role in neurotransmitter release. We recently proposed that the C-
terminal region encompassing the C1, C2B, MUN and C2C domains of Munc13-1 …

Synapses need to encode a wide dynamic range of action potential frequencies. Essential
vesicle priming proteins of the Munc13 (mammalian Unc13) family play an important role in …

Tyrosine kinases are important regulators of synaptic strength. Here, we describe a key
component of the synaptic vesicle release machinery, Munc18‐1, as a phosphorylation …