Aims Glomerular filtration rate (GFR) is difficult to assess in critically ill children using gold
standard method and alternatives are needed. This study aimed to determine the most …

Background Critically ill children frequently display observed alterations of pharmacokinetic
(PK) parameters, leading to a reduction in β-lactam concentrations. This study aimed to …

Objectives Despite that piperacillin-tazobactam combination is commonly used in critically ill
children, increasing evidence suggests that the current dosing schedules are not optimal for …

The pharmacokinetics of piperacillin were studied in 15 pediatric patients (age range, 3.3 to
14.3 years). Piperacillin was administered in a dosage of 1.5+/-0.4 g/m2 (mean+/-standard …

Objective Information regarding renal function is important in critically ill children to adjust
the dosage of drugs that are eliminated by the kidneys. Methods for estimating glomerular …

The estimated glomerular filtration rate (eGFR) equations based on serum creatinine (SCR)
have been used for pediatric dose adjustment in drug labeling. This study evaluated the …

Purpose Estimated glomerular filtration rate (eGFR) equations reflect kidney function
imprecisely. We aimed to describe whether iohexol-based GFR or eGFRs predict clearance …

Study Objective To evaluate the accuracy of four equations based on serum creatinine
concentration—the original Schwartz equation and the Leger, Bedside Chronic Kidney …

Use of a height/plasma creatinine formula to estimate glomerular filtration rate (GFR) is
simpler and less invasive than renal or plasma clearance methods. The aim of this study …

Accurate renal function assessment is crucial to guide intensive care decision-making and
drug dosing. Estimates of glomerular filtration rate (eGFR) are routinely used in critically ill …