Simple Summary Congenital lateralized or segmental overgrowth (LO) disorders are
conditions characterized by excessive tissue growth of a body region often associated with a …

Lateralized overgrowth (LO), or segmental overgrowth, is defined as an increase in growth
of tissue (bone, muscle, connective tissue, vasculature, etc.) in any region of the body. Some …

Overgrowth syndromes are a large group of rare disorders characterized by generalized or
segmental excessive growth. Segmental overgrowth syndromes are mainly due to genetic …

Lateralized/segmental overgrowth disorders (LOs) encompass a heterogeneous group of
congenital conditions with excessive body tissue growth. Documented molecular alterations …

Overgrowth disorders comprise a group of entities with a variable phenotypic spectrum
ranging from tall stature to isolated or lateralized overgrowth of body parts and or organs …

We designate a novel term “isolated lateralized overgrowth”(ILO) for the findings previously
described as “isolated hemihypertrophy” and “isolated hemihyperplasia.” ILO is defined as …

Numerous multiple malformation syndromes associated with pathologic overgrowth have
been described and, for many, their molecular bases elucidated. This review describes the …

The overgrowth syndromes are important to diagnose, not just for accurate genetic
counseling, but also for knowledge surrounding cancer surveillance and prognosis. There …

Frontiers | Developmental Mutators and Early Onset Cancer Skip to main content Download
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Overgrowth syndromes, although rare, are diagnosed more frequently lately. Major
progress, such as the identification of genetic causes, has recently enhanced the delineation …