Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …

Genetic and epigenetic alterations have been under concentrated investigations for many
years in order to unearth the molecules regulating human cancer pathogenesis. However …

Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …

Signaling pathway alterations are important in the development of gastric cancer (GC).
Deregulation of the PI3K/AKT/mTOR pathway plays a crucial role in the regulation of …

The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
pathway is one of the key signaling pathways induced by various receptor-tyrosine kinases …

Esophageal squamous cell carcinoma (ESCC), is the most common type of esophageal
cancer worldwide, mainly occurring in the Asian esophageal cancer belt, including northern …

Frequent activation of phosphatidylinositol-3 kinases (PI3K)/Akt/mTOR signaling pathway in
gastric cancer (GC) is gaining immense popularity with identification of mutations and/or …

ABSTRACT PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …

Abstract The PI3K/AKT/mTOR pathway plays a crucial role in the regulation of multiple
cellular functions including cell growth, proliferation, metabolism and angiogenesis …

Objective To analyze the correlation between sequential aspects of the phosphoinositide-3
kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway by …