Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with β-thalassemia …

AAG Tantawy, MAR Tadros, AAM Adly, EAR Ismail… - Cytokine, 2023 - Elsevier
Abstract Background: Endothelin-1 (ET-1), a potent endogenous vasoconstrictor, stimulates
production of reactive oxygen species. Endothelial monocyte-activating polypeptide-II …

Endothelial nitric oxide synthase gene intron 4 variable number tandem repeat polymorphism in β-thalassemia major: relation to cardiovascular complications

AAG Tantawy, AAM Adly, EA Ismail… - Blood Coagulation & …, 2015 - journals.lww.com
Endothelial nitric oxide synthase (eNOS), an enzyme that generates nitric oxide, is a major
determinant of endothelial function. Several eNOS gene polymorphisms have been reported …

The double heterozygote of two endothelin-1 gene polymorphisms (G8002A and-3A/-4A) is related to big endothelin levels in chronic heart failure

A Vašků, L Špinarová, M Goldbergova, J Mužík… - … and molecular pathology, 2002 - Elsevier
The aim of this study was to focus on the relationship among the associated genotypes of G
(8002) A and-3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/or …

Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients

L Špinarová, J Špinar, A Vašků… - … and molecular pathology, 2008 - Elsevier
The study objective is to prove an association among plasma concentration of big
endothelin and endothelin-1, other clinical parameters and two frequent polymorphisms …

[HTML][HTML] Association of Endothelin-1 rs5370 G> T gene polymorphism with the risk of nephrotic syndrome in children

M Hashemi, S Sadeghi-Bojd… - Journal of …, 2017 - ncbi.nlm.nih.gov
Background: Primary nephrotic syndrome (NS) is a common kidney disease in children.
Objectives: The present study was aimed to investigate whether rs5370 G> T (lys198Asn) …

Big endothelin in chronic heart failure: marker of disease severity or genetic determination?

L Špinarová, J Špinar, A Vašků, M Goldbergová… - International journal of …, 2004 - Elsevier
The first objective of the study was to compare the levels of big endothelin and endothelin-1
and other noninvasive parameters used for evaluation of disease severity in patients with …

[HTML][HTML] Association of endothelin-1 gene polymorphisms with the clinical phenotype in primary nephrotic syndrome of children

F Yang, X Lai, L Deng, X Liu, J Li, S Zeng, C Zhang… - Life sciences, 2014 - Elsevier
Aims This study aims to investigate the relationship between plasma endothelin-1 (ET-1)
concentrations, ET-1 gene polymorphisms in loci rs5370, rs1630736, 3A/4A and clinical …

Protein Z and Endothelin‐1 genetic polymorphisms in pediatric Egyptian sickle cell disease patients

MM Khorshied, NS Mohamed… - Journal of Clinical …, 2018 - Wiley Online Library
Background Sickle cell disease (SCD) is a monogenic disease associated with multisystem
morbidity. Vasculopathy caused by delicate imbalance between coagulation and endothelial …

[HTML][HTML] Association of three polymorphisms in the gene coding for endothelin-1 with essential hypertension, overweight and smoking

A Vasku, S Tschöplova, J Muzik… - … & Clinical Cardiology, 2002 - ncbi.nlm.nih.gov
OBJECTIVE: To evaluate the association of three endothelin-1 (ET-1) gene polymorphisms
with essential hypertension, as well as with two cardiovascular risk factors: body mass index …

The G-231A polymorphism in the endothelin-A receptor gene is associated with lower aortic pressure in patients with dilated cardiomyopathy

R Telgmann, BA Harb, C Ozcelik… - American journal of …, 2007 - academic.oup.com
Background: The endothelin system (ES) plays an important role in blood pressure (BP)
regulation and also in the pathophysiology of idiopathic dilated cardiomyopathy (DCM) …