This thesis thoroughly analyzed the sequence, structure, and molecular interactions of the
two major classes of protein kinases-eukaryotic and atypical. This analysis was intended to …

Kinases constitute a popular class of drug targets and to date over 60 kinase inhibitors have
been approved for clinical use by the US Food and Drug Administration (FDA). Despite the …

The discovery of selective and potent kinase inhibitors is crucial for the treatment of various
diseases, but the process is challenging due to the high structural similarity among kinases …

Owing to the intrinsic polypharmacological nature of most small-molecule kinase inhibitors,
there is a need for computational models that enable systematic exploration of the …

Since protein kinases play a fundamental role in cell signaling, especially as components of
critical growth and differentiation pathways linked to cancer, kinase inhibitors have been …

Despite decades of intensive search for compounds that modulate the activity of particular
protein targets, a large proportion of the human kinome remains as yet undrugged. Effective …

Kinase inhibitors are high-priority drug candidates for a variety of therapeutic applications.
Accordingly, there has been a rapid growth in the number of kinase inhibitors and volumes …

Large corpora of kinase small molecule inhibitor data are accessible to public sector
research from thousands of journal article and patent publications. These data have been …

Given their importance for the majority of cell physiology processes, protein kinases are
among the most extensively studied protein targets in drug discovery. Inappropriate …

Kinome-wide screening would have the advantage of providing structure–activity
relationships against hundreds of targets simultaneously. Here, we report the generation of …