[HTML][HTML] Mitochondria as potential targets in Alzheimer disease therapy: an update

G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Mitochondrial biology in Alzheimer's disease pathogenesis

MF Galindo, I Ikuta, X Zhu… - Journal of …, 2010 - Wiley Online Library
J. Neurochem.(2010) 114, 933–945. Abstract Despite the increasing knowledge of
Alzheimer's disease (AD) management with novel pharmacologic agents, most of them are …

[HTML][HTML] Targeting mitochondria in Alzheimer disease: rationale and perspectives

C Lanzillotta, F Di Domenico, M Perluigi, DA Butterfield - CNS drugs, 2019 - Springer
A decline in mitochondrial function plays a key role in the aging process and increases the
incidence of age-related disorders, including Alzheimer disease (AD). Mitochondria—the …

Mitochondrial dysfunction: different routes to Alzheimer's disease therapy

P Picone, D Nuzzo, L Caruana… - Oxidative medicine …, 2014 - Wiley Online Library
Mitochondria are dynamic ATP‐generating organelle which contribute to many cellular
functions including bioenergetics processes, intracellular calcium regulation, alteration of …

Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances

W Wang, F Zhao, X Ma, G Perry, X Zhu - Molecular neurodegeneration, 2020 - Springer
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

The role of mitochondrial dysfunction in Alzheimer's disease: A potential pathway to treatment

AB Reiss, S Ahmed, C Dayaramani, AD Glass… - Experimental …, 2022 - Elsevier
Background Alzheimer's disease (AD) is the most prevalent form of dementia worldwide and
is characterized by progressive memory loss and cognitive impairment. Our understanding …

Mitochondrial therapeutic interventions in Alzheimer's disease

V Van Giau, SSA An, JP Hulme - Journal of the neurological sciences, 2018 - Elsevier
Alzheimer's Disease (AD) is one of the most common age-related neurodegenerative
diseases in the developed world. Treatment of AD is particularly challenging as the drug …

[HTML][HTML] Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease

SN Rai, C Singh, A Singh, MP Singh, BK Singh - Molecular Neurobiology, 2020 - Springer
Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …

[HTML][HTML] Mitochondrial dysfunction in Alzheimer's disease: opportunities for drug development

S Bhatia, R Rawal, P Sharma, T Singh… - Current …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is one of the major reasons for 60-80% cases of senile dementia
occurring as a result of the accumulation of plaques and tangles in the hippocampal and …

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

JM Perez Ortiz, RH Swerdlow - British journal of pharmacology, 2019 - Wiley Online Library
Dysfunction of cell bioenergetics is a common feature of neurodegenerative diseases, the
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …