Peripheral central nervous system (CNS)–infiltrating lymphocytes are a hallmark of
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …

Cytokine dysregulation is a central driver of chronic inflammatory diseases such as multiple
sclerosis (MS). Here, we sought to determine the characteristic cellular and cytokine …

Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of
the central nervous system (CNS). Studies in rodent models demonstrated an association of …

T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …

Multiple sclerosis (MS) is characterized by pathological inflammation that results from the
recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to …

The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …

As part of a biomarker discovery effort in peripheral blood, we acquired an immunological
profile of cell-surface markers from healthy control and untreated subjects with relapsing …

Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous
system. Immune cell features are particularly promising as predictive biomarkers due to their …

Importance Cerebrospinal fluid (CSF) is the compartment in closest proximity to the central
nervous system (CNS) parenchyma and might reflect immune pathology in inflammatory …