[HTML][HTML] 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2-and H3 …
S Boccella, F Guida, M Iannotta, FA Iannotti, R Infantino… - Molecular Brain, 2021 - Springer
Neuropathic pain (NP) remains an untreatable disease due to the complex pathophysiology
that involves the whole pain neuraxis including the forebrain. Sensory dysfunctions such as …
that involves the whole pain neuraxis including the forebrain. Sensory dysfunctions such as …
[HTML][HTML] 2-pentadecyl-2-oxazoline prevents cognitive and social behaviour impairments in the Amyloid β-induced Alzheimer-like mice model: Bring the α2 adrenergic …
R Infantino, S Boccella, D Scuteri, M Perrone… - Biomedicine & …, 2022 - Elsevier
Abstract The 2-pentadecyl-2-oxazoline (PEA-OXA) is a natural compound with protective
action in neuro-inflammation. We have previously shown that PEA-OXA behaves as an α2 …
action in neuro-inflammation. We have previously shown that PEA-OXA behaves as an α2 …
[HTML][HTML] Treatment with 2-pentadecyl-2-oxazoline restores mild traumatic brain injury-induced sensorial and neuropsychiatric dysfunctions
S Boccella, M Iannotta, C Cristiano… - Frontiers in …, 2020 - frontiersin.org
Traumatic brain injury (TBI) represents an important public health problem and is followed
by neuroinflammation and neurological dysfunctions. It has been suggested that brain …
by neuroinflammation and neurological dysfunctions. It has been suggested that brain …
[HTML][HTML] Scopolamine-Induced Memory Impairment in Mice: Effects of PEA-OXA on Memory Retrieval and Hippocampal LTP
C Belardo, S Boccella, M Perrone, A Fusco… - International Journal of …, 2023 - mdpi.com
Transient global amnesia, both persistent and transient, is a very common neuropsychiatric
syndrome. Among animal models for amnesia and testing new drugs, the scopolamine test …
syndrome. Among animal models for amnesia and testing new drugs, the scopolamine test …
Differential contribution of H3R antagonism by LINS01 compounds on memory, anxiety-like behaviour and spontaneous locomotor activity in healthy rats
A Soliani, SM Kubota, MF Corrêa, SM Cerutti… - Behavioural brain …, 2020 - Elsevier
Abstract Histamine H 3 receptors (H 3 R) have attracted interest of research groups as drug
target to several CNS disorders. Data suggests that H 3 R antagonists exert neuroprotective …
target to several CNS disorders. Data suggests that H 3 R antagonists exert neuroprotective …
Neuropathic pain and reactive gliosis are reversed by dialdehydic compound in neuropathic pain rat models
MR Bianco, G Cirillo, V Petrosino, L Marcello… - Neuroscience …, 2012 - Elsevier
The role of the purinergic system in the modulation of pain mechanisms suggests that it
might be promising target for treating neuropathic pain. In this study we evaluated the effects …
might be promising target for treating neuropathic pain. In this study we evaluated the effects …
Treatment with 5-fluoro-2-oxindole increases the antinociceptive effects of morphine and inhibits neuropathic pain
P Ferreira-Chamorro, A Redondo, G Riego… - Cellular and Molecular …, 2021 - Springer
The efficacy of µ-opioid receptors (MOR) in neuropathic pain is low and with numerous side
effects that limited their use. Chronic neuropathic pain is also linked with emotional …
effects that limited their use. Chronic neuropathic pain is also linked with emotional …
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in
addition to treating depression, antidepressants such as amitriptyline are a first-line …
addition to treating depression, antidepressants such as amitriptyline are a first-line …
[HTML][HTML] Serotonin plays a key role in the development of opioid-induced hyperalgesia in mice
M Sasaki, Y Kamiya, K Bamba, T Onishi, K Matsuda… - The Journal of …, 2021 - Elsevier
Opioid usage for pain therapy is limited by its undesirable clinical effects, including
paradoxical hyperalgesia, also known as opioid-induced hyperalgesia (OIH). However, the …
paradoxical hyperalgesia, also known as opioid-induced hyperalgesia (OIH). However, the …
Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice
GW Stevenson, J Cormier, H Mercer, C Adams… - Life sciences, 2009 - Elsevier
AIMS: Pain depresses expression of many behaviors, and one goal of analgesic treatment is
to restore pain-depressed behaviors. Assays that focus on pain-depressed behaviors may …
to restore pain-depressed behaviors. Assays that focus on pain-depressed behaviors may …