Acquired abnormalities in platelets, endothelium, and their interaction occur in sepsis,
immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome …

Platelets are circulating blood cells that will normally not interact with the intact vessel wall
but that may swiftly respond to vascular disruption by adhering to subendothelial structures …

There is growing recognition of the critical role of platelets in inflammation and immune
responses. Recent studies have indicated that antiplatelet medications may reduce mortality …

Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is
associated with mortality. This thrombocytopenia is characteristic of disseminated …

The American vascular surgeons, Weismann and Tobin in 1958 1 and Roberts and
colleagues in 1964, 2 were the first to describe unusual thrombi affecting the lower limb …

Heparin-induced thrombocytopenia (HIT) is a life-and limb-threatening thrombotic disorder
that develops after exposure to heparin, often in the setting of inflammation. We have shown …

The host response to infection is a highly complex yet well-orchestrated process that
involves an elaborate array of soluble mediators (eg, components of the inflammatory and …

Since the reports by Weismann and Tobin in 1958 and Roberts et al. in 1964 called attention
to paradoxical thrombosis in patients treated with heparin, the thrombotic aspect of the …

Heparin‐induced thrombocytopenia (HIT) is an important side effect of heparin therapy
associated with significant morbidity and mortality if unrecognized. The platelet count …

Heparin-induced thrombocytopenia (HIT) is caused by heparin-dependent, platelet-
activating IgG antibodies that increase thrombin generation in vivo, producing a …