Microfluidic devices for embryonic and larval zebrafish studies

A Khalili, P Rezai - Briefings in functional genomics, 2019 - academic.oup.com
Zebrafish or Danio rerio is an established model organism for studying the genetic, neuronal
and behavioral bases of diseases and for toxicology and drug screening. The embryonic …

Fish-on-a-chip: microfluidics for zebrafish research

F Yang, C Gao, P Wang, GJ Zhang, Z Chen - Lab on a Chip, 2016 - pubs.rsc.org
High-efficiency zebrafish (embryo) handling platforms are crucially needed to facilitate the
deciphering of the increasingly expanding vertebrate–organism model values. However, the …

Designing microfluidic devices for behavioral screening of multiple zebrafish larvae

A Khalili, E van Wijngaarden, K Youssef… - Biotechnology …, 2022 - Wiley Online Library
Background Microfluidic devices are being used for phenotypic screening of zebrafish
larvae in fundamental and pre‐clinical research. A challenge for the broad use of these …

A microfluidic device for partial immobilization, chemical exposure and behavioural screening of zebrafish larvae

A Nady, AR Peimani, G Zoidl, P Rezai - Lab on a Chip, 2017 - pubs.rsc.org
The zebrafish larva is an important vertebrate model for sensory–motor integration studies,
genetic screening, and drug discovery because of its excellent characteristics such as …

Microfluidic tools for developmental studies of small model organisms–nematodes, fruit flies, and zebrafish

H Hwang, H Lu - Biotechnology journal, 2013 - Wiley Online Library
Studying the genetics of development with small model organisms such as the zebrafish
(Danio Rerio), the fruit fly (Drosophila melanogaster), and the soil‐dwelling nematode …

Miniaturized embryo array for automated trapping, immobilization and microperfusion of zebrafish embryos

J Akagi, K Khoshmanesh, B Evans, CJ Hall… - PloS one, 2012 - journals.plos.org
Zebrafish (Danio rerio) has recently emerged as a powerful experimental model in drug
discovery and environmental toxicology. Drug discovery screens performed on zebrafish …

Zebrafish embryo development in a microfluidic flow-through system

EM Wielhouwer, S Ali, A Al-Afandi, MT Blom… - Lab on a Chip, 2011 - pubs.rsc.org
The zebrafish embryo is a small, cheap, whole-animal model which may replace rodents in
some areas of research. Unfortunately, zebrafish embryos are commonly cultured in …

Fish on chips: automated microfluidic living embryo arrays

J Akagi, K Khoshmanesh, CJ Hall, KE Crosier… - Procedia …, 2012 - Elsevier
Zebrafish (Danio rerio) has recently emerged as a powerful experimental model in drug
discovery and environmental toxicology. Notwithstanding this, automated in-situ analysis of …

[PDF][PDF] Zebrafish embryos and larvae in behavioural assays

F Ahmad, LPJJ Noldus, RAJ Tegelenbosch… - …, 2012 - researchgate.net
Zebrafish embryos and early larvae are becoming increasingly important as models in
biomedical research because of their low cost, high throughput and potential as a …

Microfluidics expands the zebrafish potentials in pharmaceutically relevant screening

CY Chen, CM Cheng - Advanced healthcare materials, 2014 - Wiley Online Library
The objective of this study is to enlarge the impact of microfluidics on the pharmaceutical
industry by highlighting the reported scientific work on the synergistic relationship between …