Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases
such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a …

Synthesis of doubly 3-O-coumarylmethyl-substituted thiodigalactosides from bis-3-O-
propargyl-thiodigalactoside resulted in highly selective and high affinity galectin-3 inhibitors …

Galectins are β-galactoside-binding proteins. As carbohydrate-binding proteins, they
participate in intracellular trafficking, cell adhesion, and cell–cell signaling. Accumulating …

Discovery of glycan‐competitive galectin‐3‐binding compounds that attenuate lung fibrosis
in a murine model and that block intracellular galectin‐3 accumulation at damaged vesicles …

Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member
galectin family that are evolutionarily highly conserved. It is the only chimeric protein with a …

Introduction Galectins are ubiquitous in nature. They have established themselves as a
protein family of high therapeutic potential and play a role in a wide variety of diseases like …

Galectin-3 is a member of a family of β-galactoside-binding proteins. A substantial body of
literature reports that galectin-3 plays important roles in cancer, inflammation, and fibrosis …

Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Introduction: Galectins have affinity for β-galactosides. Human galectin-1 is ubiquitously
expressed in the body and its expression level can be a marker in disease. Targeted …

Abstract Purpose Galectin-3, a β-galactoside-binding lectin, plays a key role in several
cellular pathways involved in chronic inflammation, heart disease and cancer. GB1211 is an …