This study used various experimental pain methods to investigate the effects of subacute
mianserin administration on diabetes-induced neuropathic pain in rats. The effect of …

This study used streptozotocin-(STZ; 50 mg/kg, iv) diabetic rats and monitored the weekly
thermal nociceptive thresholds for 8-week diabetes. Nimodipine (10 mg/kg ip) treatment …

Patients with diabetes often develop peripheral nerve complications, including numbness
and pain in the extremities. Diabetes-induced peripheral neuropathic pain is characterized …

The present study was designed to investigate the anti-allodynic effects of current analgesic
agents, such as pregabalin, amitriptyline, mexiletine, morphine, and diclofenac, in a rat …

Background: Diabetic neuropathy is the most common complication of diabetes mellitus, and
the different drug combinations available do not provide effective pain relief. The present …

Aims The purpose of this study was to compare the changes of antihyperalgesic
effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late …

Diabetic neuropathic pain remains an unmet clinical problem and is poorly relieved by
conventional analgesics. N-methyl-d-aspartate (NMDA) receptors play an important role in …

Amitriptyline and gabapentin are the primary treatments for painful diabetic neuropathy
(PDN), and it is clear that they produce beneficial effects, but there are questions about …

In this study, we investigated the effects of subacute agomelatine (40 and 80 mg/kg)
administration on chronic hyperglycemia, metabolic parameters, and pain perception in …

The streptozocin-induced diabetic rat has been put forward as a model of chronic pain with
signs of hyperalgesia and allodynia that may reflect signs observed in diabetic humans. The …