The analysis of biological samples is often affected by the background matrix. Proper
sample preparation is a critical step in the analytical procedure for complex samples. In this …

To date, advanced chemical biology tools for chemoselective extraction of metabolites are
limited. In this study, unique coral-like polymer particles were synthesized via high …

We have developed a practical method for the comprehensive analysis of polar anionic
metabolites in biological samples with the use of a nano-LC/MS system. A polyamine …

As one of the most important post-translational modifications (PTM), reversible
phosphorylation of protein is involved in many cellular processes. Enrichment and …

Due to the number of phosphorylation sites, mono-and multiple-phosphopeptides exhibit
significantly different biological effects. Therefore, comprehensive profiles of mono-and …

Highly effective enrichment of phosphorylated biomolecules is vital for an in depth and
comprehensive phosphoproteome analysis. Among affinity materials, materials based on …

In this work, for the first time, perfluorinated magnetic mesoporous microspheres were
designed and synthesized for the highly specific enrichment of fluorous‐derivatized …

Playing a great role in human physiologies and pathologies, carbonyl metabolites are
intimately associated with a variety of diseases, though the effective analysis method of them …

Phosphorylation, one of the most common and important post-translational modifications of
proteins, plays a critical role in signal-transduction, regulatory, and metabolic pathways.[1] …

Protein phosphorylation is one of the most important and prevalent post-translational
modifications. Mass spectrometry (MS) has become a powerful tool for the analysis of …