The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its
ability to contract over a large length interval and to relax determines the bladder function …

PURPOSE: Much current research on lower urinary tract physiology focuses on afferent
mechanisms. The main goals are to define and control the signaling pathways by which …

Aims To discuss (1) mechanisms involved in the generation and control of myocyte
contractions and consequent afferent nerve activity and (2) these mechanisms as targets for …

The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical
contents of the lower urinary tract and the underlying tissues but also acts as a sensory …

The lower urinary tract is a muscular system composed of the urinary bladder and the
outflow tract. During filling with urine the bladder is relaxed and the outflow tract offers a high …

OBJECTIVES: This article summarizes evidence supporting the conclusion that the
spontaneous rises in pressure that occur in the overactive bladder, particularly in detrusor …

The storage and periodic elimination of urine, termed micturition, requires a complex neural
control system to coordinate the activities of the urinary bladder, urethra, and urethral …

The micturition reflex involves afferent nerve activation when the bladder is sufficiently full
and subsequent controlled firing of parasympathetic efferent nerves to contract the detrusor …

The major function of the lower urinary tract is to store and periodically evacuate urine from
the bladder. This requires coordination of the smooth muscles of the bladder and urethra …

Aims To characterize the detrusor muscle of the mouse urinary bladder in order to
understand more precisely spontaneous contractile behavior of this organ. This study …