The roles of tertiary lymphoid structures in chronic diseases

Y Sato, K Silina, M van den Broek, K Hirahara… - Nature Reviews …, 2023 - nature.com
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific
immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such …

[HTML][HTML] Developmental stages of tertiary lymphoid tissue reflect local injury and inflammation in mouse and human kidneys

Y Sato, P Boor, S Fukuma, BM Klinkhammer, H Haga… - Kidney International, 2020 - Elsevier
Tertiary lymphoid tissues (TLTs) are inducible ectopic lymphoid tissues in chronic
inflammatory states and function as sites of priming local immune responses. We previously …

The lymphatics in kidney health and disease

MD Donnan, Y Kenig-Kozlovsky… - Nature Reviews …, 2021 - nature.com
The mammalian vascular system consists of two networks: the blood vascular system and
the lymphatic vascular system. Throughout the body, the lymphatic system contributes to …

[HTML][HTML] Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis

S Jamaly, M Rakaee, R Abdi, GC Tsokos… - Autoimmunity reviews, 2021 - Elsevier
Kidney involvement confers significant morbidity and mortality in patients with systemic
lupus erythematosus (SLE). The pathogenesis of lupus nephritis (LN) involves diverse …

Understanding immune cells in tertiary lymphoid organ development: it is all starting to come together

GW Jones, DG Hill, SA Jones - Frontiers in immunology, 2016 - frontiersin.org
Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-
resolving inflammation as a result of infection, autoimmunity, cancer, and allograft rejection …

Tertiary lymphoid structures: autoimmunity goes local

E Pipi, S Nayar, DH Gardner, S Colafrancesco… - Frontiers in …, 2018 - frontiersin.org
Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune
diseases. TLS present features of secondary lymphoid organs such as segregated T and B …

Tertiary lymphoid structures are critical for cancer prognosis and therapeutic response

Q Zhang, S Wu - Frontiers in Immunology, 2023 - frontiersin.org
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates that form at sites of
chronic inflammation, including cancers, in non-lymphoid tissues. Although the formation of …

Tertiary lymphoid structures in cancer and beyond

MC Dieu-Nosjean, J Goc, NA Giraldo… - Trends in …, 2014 - cell.com
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed,
infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph …

Tertiary lymphoid structures and cytokines interconnections: the implication in cancer immunotherapy

H Li, JY Ding, MJ Zhang, HJ Yu, ZJ Sun - Cancer Letters, 2023 - Elsevier
Tertiary lymphoid structures (TLSs) are organized aggregates of lymphocytes and antigen-
presenting cells that develop in non-lymphoid tissues during chronic inflammation …

[HTML][HTML] Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Y Sato, A Mii, Y Hamazaki, H Fujita, H Nakata… - JCI insight, 2016 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is a common clinical condition defined as a rapid decline in kidney
function. AKI is a global health burden, estimated to cause 2 million deaths annually …