Protein phosphatases and kinases control multiple cellular events including proliferation,
differentiation, and stress responses through regulating reversible protein phosphorylation …

The PPM family of Ser/Thr protein phosphatases have recently been shown to down-
regulate the stress response pathways in eukaryotes. Within the stress pathway, key …

PPM [metal-dependent protein phosphatase, formerly called PP2C (protein phosphatase
2C)] family members play essential roles in regulating a variety of signalling pathways …

The heavy metal cadmium is a non-degradable pollutant. By screening the effects of a panel
of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent …

Phospho-Ser/Thr protein phosphatases (PPs) are dinuclear metalloenzymes classed into
two large families, PPP and PPM, on the basis of sequence similarity and metal ion …

Here we isolated tautomycetin, TC, and examined its phosphatase inhibitory activity.
Recently we have reported that the left-hand moiety of tautomycin, TM, and the right one …

Protein phosphatases of the type 2A family (PP2A) represent a major fraction of cellular
Ser/Thr phosphatase activity in any given human tissue. In this review, we describe how the …

Serine/threonine-specific phosphatases (PPs) represent, after protein tyrosine
phosphatases, the second major class of enzymes that catalyze the dephosphorylation of …

All known protein phosphatases specific for phosphorylated Ser and Thr are encoded by two
unrelated gene families, termed PPM and PPP (Cohen 1997; Barford, Das, and Egloff 1998) …

Protein phosphatase 2C (PP2C) is an archetype of the PPM Ser/Thr phosphatases,
characterized by dependence on divalent magnesium or manganese cofactors, absence of …