Atherosclerosis is a chronic, inflammatory disorder characterized by the deposition of excess
lipids in the arterial intima. The formation of macrophage-derived foam cells in a plaque is a …

Accumulation of atherosclerotic plaques in arterial walls leads to major cardiovascular
diseases and stroke. Macrophages/foam cells are central components of atherosclerotic …

Foam cells are a hallmark of atherosclerosis. However, it is unclear whether foam cell
formation per se protects against atherosclerosis or fuels it. In this study, we investigated the …

Atherosclerosis is associated with acute cardiovascular conditions, such as ischemic heart
disease, myocardial infarction, and stroke, and is the leading cause of morbidity and …

Macrophage-derived foam cells play integral roles in all stages of atherosclerosis. These
lipid-laden immune cells are present from the earliest discernable fatty-streak lesions to …

Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is
maintained by specialized cells, such as macrophages. Macrophages express a variety of …

Atherosclerosis is an inflammatory disease depending on the buildup, called plaque, of
lipoproteins, cholesterol, extracellular matrix elements, and various types of immune and …

Commentary the plasma. ACAT1, on the other hand is widely distributed in tissues, and
plays a pivotal role in cholesterol metabolism in steroidogenic tissues and macrophages …

The limited efficacy of current treatment strategies for targeting atherosclerosis and its
complications requires new therapeutic options to be explored. From early fatty-streak …

Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …