Sepsis currently remains a major contributor to mortality in the intensive care unit (ICU), with
48.9 million cases reported globally and a mortality rate of 22.5% in 2017, accounting for …

Sepsis is characterized by high mortality and poor prognosis and is one of the leading
causes of death among patients in the intensive care unit (ICU). In the past, drugs that block …

Sepsis is a heterogeneous syndrome comprising a highly diverse and dynamic mixture of
hyperinflammatory and compensatory anti-inflammatory immune responses. This immune …

Objective: Sepsis remains a leading cause of death in many Intensive Care Units worldwide.
Immunosuppression has been a primary focus of sepsis research as a key …

Sepsis remains a major problem for human health worldwide, thereby manifesting high rates
of morbidity and mortality. Sepsis, once understood as a monophasic sustained …

Sepsis, a leading cause of death worldwide, involves concomitant expression of an
overzealous inflammatory response and inefficient bacterial clearance. Macrophage …

Long term immunosuppression is problematic during sepsis. The PD-1 and PD-L1 immune
checkpoint proteins have potent immunosuppressive functions. Recent studies have …

Sepsis is a series of life-threatening organ dysfunction caused by an impaired host response
to infection. A large number of molecular studies of sepsis have revealed complex …

Editorial discusses the contrasting mechanisms in sepsis, hyperactivation or
immunosuppression, and the application of personalized treatment.

Monocyte dysfunction is critical to sepsis-induced immunosuppression. Programmed death
ligand-1 (PD-L1) has shown a close relationship with inflammatory disorder among animal …