Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas …

JA Reales-Calderón, F Corona, L Monteoliva, C Gil… - Journal of …, 2015 - Elsevier
Recent research indicates that the post-transcriptional regulator Crc modulates susceptibility
to antibiotics and virulence in Pseudomonas aeruginosa. Several P. aeruginosa virulence …

The global regulator Crc plays a multifaceted role in modulation of type III secretion system in Pseudomonas aeruginosa

YH Dong, XF Zhang, LH Zhang - Microbiologyopen, 2013 - Wiley Online Library
The opportunistic pathogen P seudomonas aeruginosa utilizes type III secretion system (T 3
SS) to translocate effector proteins into eukaryotic host cells that subvert normal host cell …

[HTML][HTML] Transcriptome profiling reveals links between ParS/ParR, MexEF-OprN, and quorum sensing in the regulation of adaptation and virulence in Pseudomonas …

D Wang, C Seeve, LS Pierson, EA Pierson - BMC genomics, 2013 - Springer
Abstract Background The ParS/ParR two component regulatory system plays critical roles for
multidrug resistance in Pseudomonas aeruginosa. It was demonstrated that in the presence …

[HTML][HTML] Virulence and Metabolism Crosstalk: Impaired Activity of the Type Three Secretion System (T3SS) in a Pseudomonas aeruginosa Crc-Defective Mutant

T Gil-Gil, T Cuesta, S Hernando-Amado… - International Journal of …, 2023 - mdpi.com
Pseudomonas aeruginosa is a ubiquitous nosocomial opportunistic pathogen that harbors
many virulence determinants. Part of P. aeruginosa success colonizing a variety of habitats …

[HTML][HTML] Identification of Small Molecules Blocking the Pseudomonas aeruginosa Type III Secretion System Protein PcrV

C Sundin, M Saleeb, S Spjut, L Qin, M Elofsson - Biomolecules, 2021 - mdpi.com
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that employs its type III
secretion system (T3SS) during the acute phase of infection to translocate cytotoxins into the …

The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa

JF Linares, R Moreno, A Fajardo… - Environmental …, 2010 - Wiley Online Library
The capacity of a bacterial pathogen to produce a disease in a treated host depends on the
former's virulence and resistance to antibiotics. Several scattered pieces of evidence …

[HTML][HTML] Type III Secretion Protein, PcrV, Impairs Pseudomonas aeruginosa Biofilm Formation by Increasing M1 Macrophage-Mediated Anti-bacterial Activities

H Yu, J Xiong, J Qiu, X He, H Sheng, Q Dai… - Frontiers in …, 2020 - frontiersin.org
Pseudomonas aeruginosa biofilms employ a variety of strategies to hijack the host immune
defense system to achieve chronic infection. However, the bacterial components that are …

[HTML][HTML] Structural and Molecular Mechanism of CdpR Involved in Quorum-Sensing and Bacterial Virulence in Pseudomonas aeruginosa

J Zhao, X Yu, M Zhu, H Kang, J Ma, M Wu, J Gan… - PLoS …, 2016 - journals.plos.org
Although quorum-sensing (QS) systems are important regulators of virulence gene
expression in the opportunistic human pathogen Pseudomonas aeruginosa, their detailed …

[HTML][HTML] Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles

K Koeppen, R Barnaby, AA Jackson, SA Gerber… - PloS one, 2019 - journals.plos.org
Tobramycin is commonly used to treat Pseudomonas aeruginosa lung infections in patients
with Cystic Fibrosis (CF). Tobramycin treatment leads to increased lung function and fewer …

[HTML][HTML] The Transcriptional Regulator CzcR Modulates Antibiotic Resistance and Quorum Sensing in Pseudomonas aeruginosa

G Dieppois, V Ducret, O Caille, K Perron - PloS one, 2012 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa responds to zinc, cadmium and
cobalt by way of the CzcRS two-component system. In presence of these metals the …