Galangin as an inflammatory response modulator: An updated overview and therapeutic potential

R Thapa, O Afzal, ASA Altamimi, A Goyal… - Chemico-biological …, 2023 - Elsevier
Numerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular
disease, and gastrointestinal disorders, all have an inflammation-based etiology. In cellular …

Anti-inflammatory effects of galangin on lipopolysaccharide-activated macrophages via ERK and NF-κB pathway regulation

YC Jung, ME Kim, JH Yoon, PR Park… - …, 2014 - Taylor & Francis
Inflammation is the major symptom of the innate immune response to microbial infection.
Macrophages, immune response-related cells, play a role in the inflammatory response …

[HTML][HTML] Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases

J Bai, Y Zhang, C Tang, Y Hou, X Ai, X Chen… - Biomedicine & …, 2021 - Elsevier
Gallic acid (GA), also known as 3, 4, 5-trihydroxybenzoic acid, is a natural secondary
metabolite and widely isolated from various fruits, plants and nuts. In recent years, GA has …

[HTML][HTML] Gambogic acid induces heme oxygenase-1 through Nrf2 signaling pathway and inhibits NF-κB and MAPK activation to reduce inflammation in LPS-activated …

J Ren, L Li, Y Wang, J Zhai, G Chen, K Hu - Biomedicine & …, 2019 - Elsevier
Gambogic acid (GA), a natural product with a xanthone structure, was previously
demonstrated to exert anti-inflammatory effects. The aim of this study was to evaluate the …

Anti-inflammatory mechanism of galangin in lipopolysaccharide-stimulated microglia: Critical role of PPAR-γ signaling pathway

MJ Choi, EJ Lee, JS Park, SN Kim, EM Park… - Biochemical …, 2017 - Elsevier
Since microglia-associated neuroinflammation plays a pivotal role in the progression of
neurodegenerative diseases, controlling microglial activation has been suggested as a …

Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages

Q Shi, J Cao, L Fang, H Zhao, Z Liu, J Ran… - International …, 2014 - Elsevier
Inflammatory responses are important to host immune reactions, but uncontrolled
inflammatory mediators may aid in the pathogenesis of other inflammatory diseases …

From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders

MS Hussain, G Gupta, A Goyal, R Thapa… - … of biochemical and …, 2023 - Wiley Online Library
Inflammation is an essential immune response that helps fight infections and heal tissues.
However, chronic inflammation has been linked to several diseases, including cancer …

[HTML][HTML] Flavonoids as potential anti-inflammatory molecules: A review

JM Al-Khayri, GR Sahana, P Nagella, BV Joseph… - Molecules, 2022 - mdpi.com
Hydroxylated polyphenols, also called flavonoids, are richly present in vegetables, fruits,
cereals, nuts, herbs, seeds, stems, and flowers of numerous plants. They possess numerous …

Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin

M Funakoshi-Tago, K Nakamura, K Tago… - International …, 2011 - Elsevier
Flavonoids are widely distributed in many fruits and plants, and it has been shown that most
flavonoids have anti-inflammatory activity; however, the mechanisms of how the flavonoids …

[HTML][HTML] Galangin attenuates airway remodelling by inhibiting TGF-β1-mediated ROS generation and MAPK/Akt phosphorylation in asthma

YN Liu, WJ Zha, Y Ma, FF Chen, W Zhu, A Ge… - Scientific Reports, 2015 - nature.com
Galangin, a natural flavonol, has attracted much attention for its potential anti-inflammatory
properties. However, its role in the regulation of airway remodelling in asthma has not been …