Adenovirus binds its receptor (CAR), enters cells, and replicates. It must then escape to the
environment to infect a new host. We found that following infection, human airway epithelia …

Recent identification of two receptors for the adenovirus fiber protein, coxsackie B and
adenovirus type 2 and 5 receptor (CAR), and the major histocompatibility complex (MHC) …

The adenovirus (Ad) fiber protein mediates Ad binding to the coxsackievirus and Ad receptor
(CAR) and is thus a major determinant of viral tropism. The fiber contains three domains: an …

Adenovirus is an important respiratory pathogen. Adenovirus fiber from most serotypes co-
opts the Coxsackie-Adenovirus Receptor (CAR) to bind and enter cells. However, CAR is a …

Adenovirus infection requires that the virus attach to cells and be internalized. Interaction
between the viral fiber protein and specific cell surface receptors, such as the 46-kDa …

More than 80 different adenovirus (AdV) types infect humans through the respiratory, ocular,
or gastrointestinal tracts. They cause acute clinical mani-festations or persist under humoral …

Background Viruses bind to specific cellular receptors in order to infect their hosts. The
specific receptors a virus uses are important factors in determining host range, cellular …

Human adenoviruses are nonenveloped DNA viruses that are frequently associated with
acute respiratory, gastrointestinal, and ocular infections. Among the 50 different Ad …

One of the objectives in adenovirus (Ad) vector development is to target gene delivery to
specific cell types. Major attention has been given to modification of the Ad fiber knob, which …

Attachment of an adenovirus (Ad) to a cell is mediated by the capsid fiber protein. To date,
only the cellular fiber receptor for subgroup C serotypes 2 and 5, the so-called …