[HTML][HTML] Transcriptomic insights on the virulence-controlling CsrA, BadR, RpoN, and RpoS regulatory networks in the Lyme disease spirochete

WK Arnold, CR Savage, KG Lethbridge, TC Smith 2nd… - PLoS …, 2018 - journals.plos.org
Borrelia burgdorferi, the causative agent of Lyme disease, survives in nature through a cycle
that alternates between ticks and vertebrates. To facilitate this defined lifestyle, B. burgdorferi …

[HTML][HTML] Global repression of host-associated genes of the Lyme disease spirochete through post-transcriptional modulation of the alternative sigma factor RpoS

DP Dulebohn, BM Hayes, PA Rosa - PloS one, 2014 - journals.plos.org
Borrelia burgdorferi, the agent of Lyme disease, is a vector-borne pathogen that transits
between Ixodes ticks and vertebrate hosts. During the natural infectious cycle, spirochetes …

Gene regulation and transcriptomics

DS Samuels, MC Lybecker, XF Yang, Z Ouyang… - Current issues in …, 2021 - mdpi.com
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

[HTML][HTML] Role of Acetyl-Phosphate in Activation of the Rrp2-RpoN-RpoS Pathway in Borrelia burgdorferi

H Xu, MJ Caimano, T Lin, M He, JD Radolf… - PLoS …, 2010 - journals.plos.org
Borrelia burgdorferi, the Lyme disease spirochete, dramatically alters its transcriptome and
proteome as it cycles between the arthropod vector and mammalian host. During this …

Regulation of gene and protein expression in the Lyme disease spirochete

B Stevenson, J Seshu - Spirochete Biology: The Post Genomic Era, 2018 - Springer
The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both
vertebrates and ticks, and efficient means of transmission between those two very different …

Gene Regulation in Borrelia burgdorferi

DS Samuels - Annual review of microbiology, 2011 - annualreviews.org
Borrelia burgdorferi, the spirochete that causes Lyme disease, is maintained in nature via an
enzootic cycle that comprises a tick vector and a vertebrate host. Transmission from the tick …

Rrp2, a prokaryotic enhancer-like binding protein, is essential for viability of Borrelia burgdorferi

AM Groshong, NE Gibbons, XF Yang… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT The Lyme disease spirochete, Borrelia burgdorferi, exists in two diverse niches
(ie, an arthropod tick vector and mammalian host) during its enzootic life cycle. To effectively …

[HTML][HTML] RpoS Regulates Essential Virulence Factors Remaining to Be Identified in Borrelia burgdorferi

Q Xu, Y Shi, P Dadhwal, FT Liang - PLoS One, 2012 - journals.plos.org
Background Since the RpoN-RpoS regulatory network was revealed in the Lyme disease
spirochete Borrelia burgdorferi a decade ago, both upstream and downstream of the …

[HTML][HTML] The Lyme disease spirochete, Borrelia burgdorferi, as a model vector-borne pathogen: insights on regulation of gene and protein expression

B Stevenson - Current opinion in microbiology, 2023 - Elsevier
The Lyme disease spirochete persists in nature through cycles between ticks and
vertebrates. Although the spirochete interacts with numerous, distinct tissues and …

[PDF][PDF] Two distinct mechanisms govern RpoS-mediated repression of tick-phase genes during mammalian host adaptation by Borrelia burgdorferi, the Lyme disease …

AP Grove, D Liveris, R Iyer, M Petzke, J Rudman… - 2017 - academia.edu
The alternative sigma factor RpoS plays a key role modulating gene expression in Borrelia
burgdorferi, the Lyme disease spirochete, by transcribing mammalian host-phase genes and …