Recent developments in nanoparticle‐based siRNA delivery for cancer therapy

JM Lee, TJ Yoon, YS Cho - BioMed research international, 2013 - Wiley Online Library
RNA interference (RNAi) is a gene regulation mechanism initiated by RNA molecules that
enables sequence‐specific gene silencing by promoting degradation of specific mRNAs …

Nanoparticle delivery systems for siRNA-based therapeutics

J Li, S Xue, ZW Mao - Journal of Materials Chemistry B, 2016 - pubs.rsc.org
RNA interference (RNAi) is a naturally occurring endogenous regulatory process in which
the short double-stranded RNA causes sequence-specific post-transcriptional gene …

Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities

H Isazadeh, F Oruji, S Shabani, J Behroozi… - Molecular Biology …, 2023 - Springer
Advancements in the clinical applications of small interfering RNA (siRNA) in cancer therapy
have opened up new possibilities for precision medicine. siRNAs, as powerful genetic tools …

Nanoparticle-siRNA: A potential cancer therapy?

SWS Young, M Stenzel, Y Jia-Lin - Critical reviews in oncology/hematology, 2016 - Elsevier
Purpose To explore current developments in short interfering RNA (siRNA) delivery systems
in nanooncology, in particular nanoparticles that encapsulate siRNA for targeted treatment …

Nanoparticle‐mediated siRNA delivery systems for cancer therapy

H Gao, R Cheng, H A. Santos - View, 2021 - Wiley Online Library
The small interfering RNA (siRNA)‐based therapeutics have raised great attention since the
first RNA interference (RNAi)‐derived drug, patisiran, was approved by the US Food and …

Tumor‐targeting multifunctional nanoparticles for siRNA delivery: Recent advances in cancer therapy

SH Ku, K Kim, K Choi, SH Kim… - Advanced healthcare …, 2014 - Wiley Online Library
RNA interference (RNAi) is a naturally occurring regulatory process that controls
posttranscriptional gene expression. Small interfering RNA (siRNA), a common form of RNAi …

Current progress of siRNA/shRNA therapeutics in clinical trials

JC Burnett, JJ Rossi, K Tiemann - Biotechnology journal, 2011 - Wiley Online Library
Through a mechanism known as RNA interference (RNAi), small interfering RNA (siRNA)
molecules can target complementary mRNA strands for degradation, thus specifically …

[HTML][HTML] Nanoparticle-mediated systemic delivery of siRNA for treatment of cancers and viral infections

MS Draz, BA Fang, P Zhang, Z Hu, S Gu, KC Weng… - Theranostics, 2014 - ncbi.nlm.nih.gov
RNA interference (RNAi) is an endogenous post-transcriptional gene regulatory mechanism,
where non-coding, double-stranded RNA molecules interfere with the expression of certain …

Nonviral methods for siRNA delivery

K Gao, L Huang - Molecular pharmaceutics, 2009 - ACS Publications
RNA interference (RNAi) as a mechanism to selectively degrade mRNA (mRNA) expression
has emerged as a potential novel approach for drug target validation and the study of …

Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy

E Miele, GP Spinelli, E Miele, E Di Fabrizio… - International journal …, 2012 - Taylor & Francis
During recent decades there have been remarkable advances and profound changes in
cancer therapy. Many therapeutic strategies learned at the bench, including monoclonal …