Importance Few studies have compared the use of methotrexate and biologics, the most
commonly used systemic medications for treatment of moderate to severe psoriasis in …

Background: Evidence on effectiveness and safety of methotrexate (MTX) in pediatric
psoriasis is scarce. Objectives: To study the effectiveness and safety of MTX in pediatric …

In paediatric psoriasis, few studies have evaluated methotrexate effectiveness, adverse
events and folic acid regimen. Therefore this study prospectively assessed methotrexate …

Importance Use of systemic therapies for moderate to severe psoriasis in children is
increasing, but comparative data on their use and toxicities are limited. Objective To assess …

Importance A clear dosing regimen for methotrexate in psoriasis is lacking, and this might
lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a …

The data on long‐term efficacy, safety and drug survival rates of conventional systemic
therapeutics in pediatric psoriasis is lacking. The primary aim of this study is to investigate …

Methods In this case series, data were collected on patients≤ 18 years old with moderate-to-
severe psoriasis treated with systemic medications (traditional systemic drugs or biologics) …

Background Psoriasis has an estimated prevalence of 0.5% to 2.0% in children. There is a
paucity of data regarding the management and safety of treatments currently available for …

Well‐designed studies on systemic therapeutic modalities for severe psoriasis in children
are rare. Children with severe disease are treated with the support of data extrapolated from …

Background Psoriasis is a chronic, immune-mediated inflammatory disease with prominent
cutaneous features, although the limited number of medications approved for pediatric …