Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis
R Dobie, JR Wilson-Kanamori, BEP Henderson… - Cell reports, 2019 - cell.com
Iterative liver injury results in progressive fibrosis disrupting hepatic architecture,
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …
Single cell RNA sequencing identifies subsets of hepatic stellate cells and myofibroblasts in liver fibrosis
O Krenkel, J Hundertmark, TP Ritz, R Weiskirchen… - Cells, 2019 - mdpi.com
Activation of hepatic stellate cells (HSCs) and their trans-differentiation towards collagen-
secreting myofibroblasts (MFB) promote liver fibrosis progression. During chronic liver …
secreting myofibroblasts (MFB) promote liver fibrosis progression. During chronic liver …
[PDF][PDF] Single‐cell transcriptomic analysis reveals a hepatic stellate cell–activation roadmap and myofibroblast origin during liver fibrosis in mice
Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …
[PDF][PDF] Transcriptional dynamics of hepatic sinusoid‐associated cells after liver injury
MK Terkelsen, SM Bendixen, D Hansen… - …, 2020 - Wiley Online Library
Background and Aims Hepatic sinusoidal cells are known actors in the fibrogenic response
to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and …
to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and …
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
I Mederacke, CC Hsu, JS Troeger, P Huebener… - Nature …, 2013 - nature.com
Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the
lack of detailed knowledge about specific cellular contributors mediating fibrogenesis …
lack of detailed knowledge about specific cellular contributors mediating fibrogenesis …
Hepatic stellate cell regulation of liver regeneration and repair
LJ Kitto, NC Henderson - Hepatology Communications, 2021 - journals.lww.com
The hepatic mesenchyme has been studied extensively in the context of liver fibrosis;
however, much less is known regarding the role of mesenchymal cells during liver …
however, much less is known regarding the role of mesenchymal cells during liver …
[PDF][PDF] Single‐cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver
JK Morrison, C DeRossi, IL Alter… - Hepatology …, 2022 - Wiley Online Library
The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no
approved antifibrotic treatments available. The adult zebrafish has been an underutilized …
approved antifibrotic treatments available. The adult zebrafish has been an underutilized …
[HTML][HTML] Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis
BK Chung, J Øgaard, HM Reims… - Hepatology …, 2022 - journals.lww.com
Liver fibrosis and cirrhosis have limited therapeutic options and represent a serious unmet
patient need. Recent use of single‐cell RNA sequencing (scRNAseq) has identified …
patient need. Recent use of single‐cell RNA sequencing (scRNAseq) has identified …
Initiation of hepatic stellate cell activation extends into chronic liver disease
V De Smet, N Eysackers, V Merens… - Cell Death & …, 2021 - nature.com
Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …
Friend or foe? The elusive role of hepatic stellate cells in liver cancer
B Cogliati, CN Yashaswini, S Wang, D Sia… - Nature Reviews …, 2023 - nature.com
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
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