Iterative liver injury results in progressive fibrosis disrupting hepatic architecture,
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …

Activation of hepatic stellate cells (HSCs) and their trans-differentiation towards collagen-
secreting myofibroblasts (MFB) promote liver fibrosis progression. During chronic liver …

Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …

Background and Aims Hepatic sinusoidal cells are known actors in the fibrogenic response
to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and …

Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the
lack of detailed knowledge about specific cellular contributors mediating fibrogenesis …

The hepatic mesenchyme has been studied extensively in the context of liver fibrosis;
however, much less is known regarding the role of mesenchymal cells during liver …

The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no
approved antifibrotic treatments available. The adult zebrafish has been an underutilized …

Liver fibrosis and cirrhosis have limited therapeutic options and represent a serious unmet
patient need. Recent use of single‐cell RNA sequencing (scRNAseq) has identified …

Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …