Metabolic enzyme loci were some of the first genes accessible for molecular evolution and
ecology research. New technologies now make the whole genome, transcriptome or …

▪ Abstract Allozyme polymorphisms have been the focus of studies of selection at single
enzyme loci, and most involve the enzymes of central metabolism. DNA sequencing of …

Identification of the causal genes that control complex trait variation remains challenging,
limiting our appreciation of the evolutionary processes that influence polymorphisms in …

In this review, I discuss the evidence for differential natural selection acting across enzymes
in the glycolytic pathway in Drosophila. Across the genome, genes evolve at very different …

Background Cellular metabolism is a fundamental biological system consisting of myriads of
enzymatic reactions that together fulfill the basic requirements of life. The recent availability …

The adaptive significance of enzyme variation has been of central interest in population
genetics. Yet, how natural selection operates on enzymes in the larger context of …

Background Determining the factors involved in the likelihood of a gene being under
adaptive selection is still a challenging goal in Evolutionary Biology. Here, we perform an …

Daniel E. Dykhuizen and Antony M. Dean laws all too often rely on consistency arguments-
the 'just-so'storiesj. Hence, our understanding of evolution remains incomplete. Can the …

Metabolic rate reflects an organism's capacity for growth, maintenance and reproduction,
and is likely to be a target of selection. Physiologists have long sought to understand the …

The ability to control the rates of metabolic processes in response to changes in the internal
or external environment is an indispensable attribute of living cells that must have arisen …