Structural modification of imiquimod (1), which is known as an interferon-α (IFN-α) inducer,
for the aim of finding a novel and small-molecule tumor necrosis factor-α (TNF-α) suppressor …

Tumor necrosis factor-α is an important pro-inflammatory cytokine having a key role in hosts
defensive process of immune systems and its over expression led to a diverse range of …

In a previous study, we analysed the synthesis and properties of a series of imidazo [1, 2-a]
quinoxalines designed in our laboratory as possible imiquimod analogues. We found that …

1 H-Imidazo-[4, 5-c] quinolines were prepared while investigating novel nucleoside
analogues as potential antiviral agents. While these compounds showed no direct antiviral …

Recently, a new class of immunomodulating agents, represented by the molecules
imiquimod and R-842, has demonstrated potent antiviral and antitumor activities in animal …

We herein describe the synthesis and anti-inflammatory properties of a small library of
imidazoline-based NF-κB inhibitors. The structure–activity relationship of various …

Imiquimod (S-26308, R-837)(1-(2-methylpropyl)-1H-imidazo [4, 5-c] quinolin-4 amine), an
immune response modifier, demonstrates potent antiviral and antitumor activity in animal …

Novel hexahydroimidazo [1, 2-a] pyridines prepared by the addition of ethyl (1-
benzylimidazolidin-2-ylidene) acetate (2) to the fungal metabolite podoscyphic acid (1a) and …

Nuclear factor–κB (NF–κB) is an important nuclear transcription factor which regulates pro‐
inflammatory cytokines such as TNF‐α, IL‐6. Its role as immunoregulatory mediator makes it …

Toll-like receptors 7 and 8 (TLRs) have emerged as key targets in the design of small
molecule adjuvants and stimulants for use in immunotherapies. This study examines the …