Defects in pituitary gland organogenesis are sometimes associated with congenital
anomalies that affect head development. Lesions in transcription factors and signaling …

Pituitary organogenesis is a highly complex and tightly regulated process that depends on
several transcription factors (TFs), such as PROP1, PIT1 (POU1F1), HESX1, LHX3 and …

Development of the pituitary gland and pituitary cell determination and specification depend
on the expression and interaction of signaling molecules and transcription factors in …

The pituitary gland functions as a relay between the hypothalamus and peripheral target
organs that regulate basic physiological functions, including growth, the stress response …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

Hypopituitarism is defined as the deficiency of one or more of the hormones secreted by the
pituitary gland. Several developmental factors necessary for pituitary embryogenesis and …

Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from
the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to …

Many aspects of pituitary development have become better understood in the past two
decades. The signaling pathways regulating pituitary growth and shape have emerged, and …

Significant advances have been made in defining the transcription cascade that is
responsible for the early steps of pituitary formation and the environmental signals that …

Basic and translational research achievements over the past 2 decades have disclosed the
molecular mechanisms underlying several genetic forms of hypopituitarism. Disorders that …