Molecular mechanisms of pituitary organogenesis: in search of novel regulatory genes
Defects in pituitary gland organogenesis are sometimes associated with congenital
anomalies that affect head development. Lesions in transcription factors and signaling …
anomalies that affect head development. Lesions in transcription factors and signaling …
Pituitary development: a complex, temporal regulated process dependent on specific transcriptional factors.
DC de Moraes, M Vaisman, FL Conceicao… - The Journal of …, 2012 - europepmc.org
Pituitary organogenesis is a highly complex and tightly regulated process that depends on
several transcription factors (TFs), such as PROP1, PIT1 (POU1F1), HESX1, LHX3 and …
several transcription factors (TFs), such as PROP1, PIT1 (POU1F1), HESX1, LHX3 and …
Genetic disorders of the pituitary
LE Cohen - Current Opinion in Endocrinology, Diabetes and …, 2012 - journals.lww.com
Development of the pituitary gland and pituitary cell determination and specification depend
on the expression and interaction of signaling molecules and transcription factors in …
on the expression and interaction of signaling molecules and transcription factors in …
Genetic regulation of pituitary gland development in human and mouse
Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …
dependent upon a complex genetic cascade of transcription factors and signaling molecules …
Genetic control of pituitary development and hypopituitarism
X Zhu, CR Lin, GG Prefontaine, J Tollkuhn… - Current opinion in …, 2005 - Elsevier
The pituitary gland functions as a relay between the hypothalamus and peripheral target
organs that regulate basic physiological functions, including growth, the stress response …
organs that regulate basic physiological functions, including growth, the stress response …
The molecular basis of hypopituitarism
CJ Romero, S Nesi-França, S Radovick - Trends in Endocrinology & …, 2009 - cell.com
Hypopituitarism is defined as the deficiency of one or more of the hormones secreted by the
pituitary gland. Several developmental factors necessary for pituitary embryogenesis and …
pituitary gland. Several developmental factors necessary for pituitary embryogenesis and …
Molecular basis of combined pituitary hormone deficiencies
LE Cohen, S Radovick - Endocrine Reviews, 2002 - academic.oup.com
Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from
the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to …
the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to …
Pituitary gland development and disease: from stem cell to hormone production
SW Davis, BS Ellsworth, MIP Millan, P Gergics… - Current topics in …, 2013 - Elsevier
Many aspects of pituitary development have become better understood in the past two
decades. The signaling pathways regulating pituitary growth and shape have emerged, and …
decades. The signaling pathways regulating pituitary growth and shape have emerged, and …
Early steps in pituitary organogenesis
HZ Sheng, H Westphal - Trends in Genetics, 1999 - cell.com
Significant advances have been made in defining the transcription cascade that is
responsible for the early steps of pituitary formation and the environmental signals that …
responsible for the early steps of pituitary formation and the environmental signals that …
Heritable disorders of pituitary development
JS Parks, MR Brown, DL Hurley… - The Journal of …, 1999 - academic.oup.com
Basic and translational research achievements over the past 2 decades have disclosed the
molecular mechanisms underlying several genetic forms of hypopituitarism. Disorders that …
molecular mechanisms underlying several genetic forms of hypopituitarism. Disorders that …