Enteroviruses are believed to contribute to the pathogenesis of type 1 diabetes mellitus
(T1DM). In this Review, the interplay between infection with enteroviruses, the immune …

Environmental factors, especially viruses, are involved in the initiation or the acceleration of
type 1 diabetes (T1D) pathogenesis. Epidemiological data strongly suggest that …

Type 1 (insulin-dependent) diabetes is a typical organ-specific autoimmune disease where
insulin-producing beta cells are destroyed by immune mediated mechanisms. The risk of the …

Highlights•Enteroviral infection has been long-associated with type 1 diabetes in
epidemiological studies.•β-Cells express a specific enteroviral receptor isoform, CAR-SIV …

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency
and resultant hyperglycemia. Complex interactions of genetic and environmental factors …

The question if enteroviruses could cause beta-cell damage and type 1 diabetes has
become more and more relevant when recent studies have provided new evidence …

Considerable evidence implies that an enteroviral infection may accelerate or precipitate
type 1 diabetes (T1D) in some individuals. However, causality is not proven. We present and …

Summary OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW
SERIES Metabolic diseases, host responses, cancer, autoinflammatory diseases, allergy …

Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which the immune system
mounts an attack on the host's insulin‐producing β cells. Because most cases of T1D cannot …