Marfan syndrome (MFS) is a connective tissue disorder with multiple organ manifestations.
The genetic cause of this syndrome is the mutation of the FBN1 gene, encoding the …

Marfan syndrome (MFS) is an inherited autosomal dominant multisystem disease caused by
mutations in the FBN1 gene encoding fibrillin-1, an extracellular matrix glycoprotein widely …

Marfan syndrome (MFS) is a genetic disorder that affects multiple organs. Mortality imposed
by aortic aneurysm and dissections represent the most serious clinical manifestation of MFS …

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by
fibrillin 1 (FBN1) gene mutations that results in defects in the skeletal, ocular, and …

Marfan syndrome (MFS) is caused by mutations in the protein fibrillin-1 (FBN1) which affects
the integrity of connective tissue elastic fibres. The most severe clinical outcome is the …

Thoracic aortic aneurysm (TAA) is the life-threatening complication of Marfan syndrome
(MFS), a connective tissue disorder caused by mutations in the fibrillin-1 gene. TAA is …

Marfan syndrome (MFS) is one of the most common inherited disorders of connective tissue
caused by mutations of the fibrillin-1 gene (FBN1). Vascular abnormalities, such as the …

Objective: Marfan syndrome (MFS) is caused by mutations in FBN1 (fibrillin-1), an
extracellular matrix (ECM) component, which is modified post-translationally by …

Dissecting aortic aneurysm is the hallmark of Marfan syndrome (MFS) and the result of
mutations in fibrillin-1, the major constituent of elastin-associated extracellular microfibrils. It …

Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of
connective tissue with prominent manifestations in the skeletal, ocular, and cardiovascular …