The cell cycle: a critical therapeutic target to prevent vascular proliferative disease

T Charron, N Nili, BH Strauss - Canadian Journal of Cardiology, 2006 - Elsevier
Percutaneous coronary intervention is the preferred revascularization approach for most
patients with coronary artery disease. However, this strategy is limited by renarrowing of the …

Cell cycle progression: new therapeutic target for vascular proliferative disease

RC Braun-Dullaeus, MJ Mann, VJ Dzau - Circulation, 1998 - Am Heart Assoc
Entry into and progression of vascular cells through the cell cycle is considered a key event
in vascular proliferative diseases. Multiple growth factors and cytokines have been found to …

Cell cycle in vasculoproliferative diseases: potential interventions and routes of delivery

V Sriram, C Patterson - Circulation, 2001 - Am Heart Assoc
Atherosclerosis and restenosis of epicardial vessels are among the greatest challenges
facing the clinical cardiologist, and phenotypic modulation and proliferation of smooth …

Break the cycle: the role of cell-cycle modulation in the prevention of vasculoproliferative diseases

JE Ferguson, C Patterson - Cell cycle, 2003 - Taylor & Francis
Atherosclerosis is a major health problem in the western world, and the effectiveness of
interventional therapeutic modalities for symptomatic atherosclerotic lesions is limited by …

Reprogramming the cell cycle machinery to treat cardiovascular disease

KA Bicknell, G Brooks - Current Opinion in Pharmacology, 2008 - Elsevier
Coronary artery disease is one of the most common heart pathologies. Restriction of blood
flow to the heart by atherosclerotic lesions, leading to angina pectoris and myocardial …

[HTML][HTML] Atherosclerosis and cell cycle: put the brakes on! Critical role for cyclin-dependent kinase inhibitors

R Wessely - Journal of the American College of Cardiology, 2010 - jacc.org
Regulation of cellular proliferation constitutes one of the fundamental mechanisms of
biology. In the context of cardiovascular disease, imbalances in the delicate equilibrium …

Control of vascular smooth muscle cell growth and its implication in atherosclerosis and restenosis

V Andres - International journal of molecular medicine, 1998 - spandidos-publications.com
Abnormal proliferation of vascular smooth muscle cells (SMCs) is thought to contribute to
neointimal thickening during spontaneous atherosclerosis and vessel renarrowing …

Antiproliferative strategies for the treatment of vascular proliferative disease

V Andrs, C Castro - Current vascular pharmacology, 2003 - ingentaconnect.com
Excessive cellular proliferation contributes to the pathobiology of vascular obstructive
diseases (eg, atherosclerosis, in-stent restenosis, transplant vasculopathy, and vessel …

Targeting the cell cycle machinery for the treatment of cardiovascular disease

KA Bicknell, EL Surry, G Brooks - Journal of pharmacy and …, 2003 - Wiley Online Library
Cardiovascular disease represents a major clinical problem affecting a significant proportion
of the world's population and remains the main cause of death in the UK. The majority of …

[PDF][PDF] Cell cycle molecules and diseases of the cardiovascular system

SB Petkova, A Ashton, B Bouzahzah, H Huang… - Front …, 2000 - article.imrpress.com
[Frontiers in Bioscience 5, d452-460, April 1, 2000] 452 CELL CYCLE MOLECULES AND
DISEASES OF THE CARDIOVASCULAR SYSTEM Stefka B Page 1 [Frontiers in Bioscience 5 …