Patients with cancer can develop recurrent metastatic disease with latency periods that
range from years even to decades. This pause can be explained by cancer dormancy, a …

Tumor dormancy is a phenomenon whereby cancer cells persist below the threshold of
diagnostic detection for months to decades. This condition may arise due to either cell cycle …

Disease relapse in cancer patients many years after clinical remission, often referred to as
cancer dormancy, is well documented but remains an incompletely understood …

Clinical cancer dormancy is defined as an unusually long time between removal of the
primary tumor and subsequent relapse in a patient who has been clinically disease-free …

Cancer dormancy is a stage in tumor progression in which residual disease remains occult
and asymptomatic for a prolonged period of time. Dormant tumor cells can be present as …

Species evolve by mutations and epigenetic changes acting on individuals in a population;
tumors evolve by similar mechanisms at a cellular level in a tissue. This article reviews …

The increasing number of cancer survivors is cause for celebration, but this expanding
population has highlighted the problem of tumour dormancy, which can lead to relapse. As …

One of the most formidable challenges in oncology and tumor biology research is to provide
an accurate understanding of tumor dormancy mechanisms. Dormancy refers to the ability of …

The reactivation of cancer cells following a seemingly successful treatment of the primary
tumour with initial therapies (such as tumour excision or systemic therapy) is a well-known …

Evidence suggests that dormant, microscopic tumors are not only common, but are highly
prevalent in otherwise healthy individuals. Due to their small size and non-invasive nature …