The three-dimensional arrangement of the human genome comprises a complex network of
structural and regulatory chromatin loops important for coordinating changes in transcription …

To infer potential causal relationships between 3D chromatin structure, enhancers, and
gene transcription, we mapped each feature in a genome-wide fashion across eight …

Higher-order chromosomal organization for transcription regulation is poorly understood in
eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag …

Immunocytes dynamically reprogram their gene expression profiles during differentiation
and immunoresponse. However, the underlying mechanism remains elusive. Here, we …

Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

Genome-scale studies have revealed extensive, cell type-specific colocalization of
transcription factors, but the mechanisms underlying this phenomenon remain poorly …

During embryogenesis, precise gene transcription in space and time requires that distal
enhancers and promoters communicate by physical proximity within gene regulatory …

Cellular differentiation is orchestrated by lineage-specific transcription factors and
associated with cell type–specific epigenetic signatures. In the present study, we used stage …

Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

Gene expression patterns in complex multicellular organisms are regulated by enhancers,
which communicate with their target gene promoters in three-dimensional (3D) chromatin …