Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14. 13.39). They all utilize l-arginine and molecular oxygen as …

▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The …

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …

Endothelial nitric oxide synthase (eNOS, NOS3) is responsible for producing nitric oxide
(NO)—a key molecule that can directly (or indirectly) act as a vasodilator and anti …

This article explores the physiology of superoxide generation by endothelial nitric oxide
synthase (eNOS), the so-called “uncoupled” state of the enzyme. The fact that this alternative …

Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to
anti‐proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the …

In many types of cardiovascular pathophysiology such as hypercholesterolemia and
atherosclerosis, diabetes, cigarette smoking, or hypertension (with its sequelae stroke and …

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three
distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and …

The pathogenesis of many cardiovascular diseases is associated with reduced nitric oxide
(NO) bioavailability and/or increased endothelial NO synthase (eNOS)-dependent …

Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the
potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of …