Thyroid cancer, which represents the most common tumors among endocrine malignancies,
comprises a wide range of neoplasms with different clinical aggressiveness. One of the most …

Genetically engineered and orthotopic xenograft mouse models have been instrumental for
increasing our understanding of thyroid cancer progression and for the development of …

Simple Summary According to the American Cancer Society, approximately 53,000 new
cases of thyroid cancer were diagnosed and more than 2200 people died from the disease …

Thyroid cancer is the most common endocrine neoplasm, and its rate is rising at an alarming
pace. Thus, there is a compelling need to develop in vivo models which will not only enable …

Poorly differentiated thyroid cancer (PDTC) and undifferentiated thyroid cancer (UDTC) are
still lifethreatening pathologies, because of the lack of wellestablished diagnostic and …

Thyroid cancer incidence has been increasing over time, and it is estimated that∼ 1950
advanced thyroid cancer patients will die of their disease in 2015. To combat this disease …

Therapies targeting specific tumor pathways are easy to enter the clinic. To monitor
molecular changes, cellular processes, and tumor microenvironment, molecular imaging is …

There is a need for a clinically relevant mouse model of thyroid cancer that enables real-
time, non-invasive monitoring of tumor growth, progression, and drug response over time …

A significant number of well-differentiated thyroid cancers progress or recur, becoming
resistant to current therapeutic options. Mouse models recapitulating the genetic and …

Thyroid carcinomas, the most common endocrine tumors in humans, have an increasing
incidence in the US and worldwide. There are four major types of thyroid cancers: papillary …