Induced pluripotent stem cells and their use in human models of disease and development

P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

[HTML][HTML] Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery

VK Singh, M Kalsan, N Kumar, A Saini… - Frontiers in cell and …, 2015 - frontiersin.org
Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …

Induced pluripotent stem cells in medicine and biology

K Takahashi, S Yamanaka - Development, 2013 - journals.biologists.com
Differentiated cells can be reprogrammed to pluripotency and other cell fates by treatment
with defined factors. The discovery of induced pluripotent stem cells (iPSCs) has opened up …

[HTML][HTML] Induced pluripotent stem cells and personalized medicine: current progress and future perspectives

YS Chun, K Byun, B Lee - Anatomy & cell biology, 2011 - synapse.koreamed.org
Generation of induced pluripotent stem cells (iPSCs) has revolutionized the field of
regenerative medicine by providing researchers with a unique tool to derive disease-specific …

[HTML][HTML] Induced pluripotent stem cells, a giant leap for mankind therapeutic applications

J Bragança, JA Lopes, L Mendes-Silva… - World journal of stem …, 2019 - ncbi.nlm.nih.gov
Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells
biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer …

Harnessing the potential of induced pluripotent stem cells for regenerative medicine

SM Wu, K Hochedlinger - Nature cell biology, 2011 - nature.com
The discovery of methods to convert somatic cells into induced pluripotent stem cells
(iPSCs) through expression of a small combination of transcription factors has raised the …

[HTML][HTML] Induced pluripotent stem cells (iPSCs)—roles in regenerative therapies, disease modelling and drug screening

MAM Aboul-Soud, AJ Alzahrani, A Mahmoud - Cells, 2021 - mdpi.com
The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

G Tiscornia, EL Vivas, JCI Belmonte - Nature medicine, 2011 - nature.com
The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic
syndromes offers new opportunities for basic research into these diseases and the …

iPS cell technology in regenerative medicine

CJ Lengner - Annals of the New York Academy of Sciences, 2010 - Wiley Online Library
The promise of treating human genetic and degenerative diseases through the application
of pluripotent cell‐based tissue engineering and regenerative medicine has come …

Present and future challenges of induced pluripotent stem cells

M Ohnuki, K Takahashi - Philosophical Transactions of …, 2015 - royalsocietypublishing.org
Growing old is our destiny. However, the mature differentiated cells making up our body can
be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate …