MPO and EPO are mammalian heme peroxidase enzymes that play a role in a wide range of
human pathologies [934]. The bactericidal activity of leukocytes is attributed to MPO [934] …

S100A8 and S100A9 are generally considered proinflammatory. Hypohalous acids
generated by activated phagocytes promote novel modifications in murine S100A8 but …

S100A8 and S100A9 are two soluble calcium-binding proteins highly expressed in myeloid
cells, mainly neutrophils (45% of cytosolic proteins) or monocytes (1-5%) and also early …

Reactive oxygen species (ROS) are low-molecular-weight inorganic and highly reactive
compounds that are produced during normal aerobic cell metabolism. At low level, ROS …

The members of the S100 protein family compose a multigenic family of non-ubiquitous
cytoplasmic Ca2+-binding proteins of EF-hand type that are differentially expressed in a …

Summary Human myeloperoxidase (MPO; EC 1.11. 1.7) is a specific heme (Fe 3+)
peroxidase, present in high concentrations in the azurophilic granules of neutrophils. Its …

The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

The heme protein myeloperoxidase (MPO) is a major constituent of neutrophils. As a key
mediator of the innate immune system, neutrophils are rapidly recruited to inflammatory …